Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MTOR | P42345 | 2/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452088 | 0.92 | MAPT (1.00) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL14271150 | 0.87 | MAPT (0.84) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL4939159 | 0.84 | PIK3CA (0.64) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL10830558 | 0.83 | HTT (0.80) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL3353780 | 0.83 | NPSR1 (0.69) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL13153211 | 0.81 | MTOR (0.61) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL14271149 | 0.81 | NPSR1 (0.78) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL3451098 | 0.80 | NPSR1 (0.72) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL628064 | 0.79 | MAPT (0.55) | MAPTNPSR1TSHRHSD17B10MAPK1 | |
| SCHEMBL1029661 | 0.78 | HTT (0.80) | MAPTNPSR1TSHRHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |