Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.67 |
| ▸ | MTOR | P42345 | 14/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.64 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828813 | 0.84 | MTOR (0.70) | PIK3CAMTORPIK3CG | |
| SCHEMBL2152954 | 0.82 | MTOR (0.74) | MTOR | |
| SCHEMBL3730124 | 0.82 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL12463278 | 0.82 | MTOR (0.74) | PIK3CAMTORPIK3CG | |
| SCHEMBL32391 | 0.81 | PIK3CA (0.73) | PIK3CAMTORPIK3CG | |
| SCHEMBL2369790 | 0.81 | PIK3CA (0.78) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3721523 | 0.81 | PIK3CA (0.75) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL13828767 | 0.81 | MTOR (0.81) | PIK3CAMTORPIK3CG | |
| SCHEMBL2370051 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL13828733 | 0.80 | MTOR (0.72) | PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |