Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710525 | 0.86 | PIK3CA (0.55) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3705975 | 0.85 | ABL1 (0.59) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3711260 | 0.84 | ABL1 (0.54) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3711773 | 0.82 | ABL1 (0.56) | ABL1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13188976 | 0.81 | ABL1 (0.55) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13188408 | 0.81 | ABL1 (0.58) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13188978 | 0.81 | ABL1 (0.52) | ABL1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3807814 | 0.80 | ABL1 (0.52) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13189184 | 0.80 | ABL1 (0.49) | ABL1PIK3CGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13188323 | 0.80 | ABL1 (0.49) | ABL1NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |