Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 7/20 | 0.74 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 1/20 | 0.74 |
| ▸ | CA2 | P00918 | 1/20 | 0.74 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.74 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.74 |
| ▸ | ITGAL | P20701 | 1/20 | 0.74 |
| ▸ | CA4 | P22748 | 1/20 | 0.74 |
| ▸ | CA6 | P23280 | 1/20 | 0.74 |
| ▸ | ADK | P55263 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL30463845 | 0.86 | — | — | |
| Indole SCHEMBL28071644 | 0.86 | AHR (1.00) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL30250492 | 0.86 | — | — | |
| Indole SCHEMBL1160186 | 0.86 | AHR (1.00) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL698 | 0.86 | — | — | |
| Indole SCHEMBL29352896 | 0.86 | — | — | |
| Indole SCHEMBL22534012 | 0.84 | AHR (0.77) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL6791278 | 0.84 | AHR (0.85) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28020016 | 0.84 | AHR (0.85) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL25404194 | 0.84 | AHR (0.94) | AHRTRPA1CA1CA2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121382-A1 | PROCESS FOR MAKING INDOLE CYCLOPROPYL AMIDE DERIVATIVES | MERCK FROSST CANADA LTD. (CA) | 2010-10-28 | — | — | WO | disclosed |