Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.56 |
| ▸ | AKT1 | P31749 | 10/20 | 0.56 |
| ▸ | MTOR | P42345 | 8/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188175 | 0.89 | PIK3CG (0.64) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3715092 | 0.87 | PIK3CG (0.61) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3869294 | 0.87 | PIK3CG (0.66) | PIK3CGPIK3CAAKT1MTORABL1 | |
| SCHEMBL3712282 | 0.86 | PIK3CA (0.61) | PIK3CGPIK3CAAKT1MTOR | |
| SCHEMBL3877563 | 0.85 | PIK3CG (0.69) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3719581 | 0.83 | PIK3CG (0.61) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3869295 | 0.82 | PIK3CG (0.72) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3705799 | 0.82 | PIK3CG (0.62) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3713333 | 0.82 | PIK3CG (0.59) | PIK3CGPIK3CAAKT1MTORCYP3A4 | |
| SCHEMBL3709005 | 0.82 | PIK3CG (0.61) | PIK3CGPIK3CAAKT1MTORCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |