Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.65 |
| ▸ | MTOR | P42345 | 18/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721784 | 0.90 | PIK3CA (0.60) | PIK3CAMTORPIK3CG | |
| SCHEMBL3722645 | 0.90 | MTOR (0.68) | PIK3CAMTORPIK3CG | |
| SCHEMBL3723931 | 0.89 | MTOR (0.55) | PIK3CAMTORPIK3CG | |
| SCHEMBL3718813 | 0.88 | MTOR (0.52) | PIK3CAMTORPIK3CG | |
| SCHEMBL3727701 | 0.88 | MTOR (0.52) | PIK3CAMTORPIK3CG | |
| SCHEMBL3718841 | 0.87 | PIK3CA (0.71) | PIK3CAMTORPIK3CG | |
| SCHEMBL3721727 | 0.87 | MTOR (0.51) | PIK3CAMTORPIK3CG | |
| SCHEMBL3721353 | 0.87 | PIK3CA (0.70) | PIK3CAMTORPIK3CG | |
| SCHEMBL3727683 | 0.87 | MTOR (0.52) | PIK3CAMTOR | |
| SCHEMBL3721051 | 0.86 | MTOR (0.71) | PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |