Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690044 | 0.84 | HSP90AB1 (0.50) | HSP90AB1ALDH1A1POLBSMN1; SMN2TSHR | |
| SCHEMBL1364993 | 0.84 | PTPN11 (0.39) | KDM4EHSP90AB1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1366043 | 0.79 | MKNK1 (0.40) | HSP90AB1POLBSMN1; SMN2 | |
| SCHEMBL1020021 | 0.79 | POLB (0.72) | KDM4EHSP90AB1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24920531 | 0.78 | HSP90AB1 (0.56) | KDM4EHSP90AB1ALDH1A1POLBHSP90AA1 | |
| SCHEMBL12142170 | 0.76 | HSP90AB1 (0.35) | HSP90AB1ALDH1A1POLBSMN1; SMN2HSP90AA1 | |
| SCHEMBL12143536 | 0.76 | HSP90AB1 (0.37) | HSP90AB1ALDH1A1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL17624125 | 0.75 | HSP90AB1 (0.50) | KDM4EHSP90AB1ALDH1A1POLBMAPK1 | |
| SCHEMBL2807505 | 0.75 | POLB (0.56) | KDM4EHSP90AB1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24921798 | 0.75 | HSP90AB1 (0.47) | KDM4EHSP90AB1ALDH1A1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120987-A1 | RING FUSED, UREIDOARYL- AND CARBAMOYLARYL-BRIDGED MORPHOLINO-PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |