Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721114 | 0.80 | MGAM (0.52) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL3095816 | 0.77 | MGAM (0.64) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL3095833 | 0.77 | MGAM (0.64) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL3095823 | 0.77 | MGAM (0.64) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL6784461 | 0.76 | MGAM (0.58) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL6784466 | 0.76 | MGAM (0.62) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL610575 | 0.76 | MGAM (0.61) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL1765966 | 0.76 | MGAM (0.65) | MGAMCFTRTOP2ATOP2BCYP1A2 | |
| SCHEMBL13096310 | 0.74 | KDM4E (0.58) | MGAMCFTRCYP1A2MAP4K4CSNK1G2 | |
| SCHEMBL3396690 | 0.72 | MGAM (0.65) | MGAMCFTRTOP2ATOP2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |