Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 2/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704113 | 0.81 | GRIN1 (0.34) | — | |
| SCHEMBL2822729 | 0.79 | HIF1A (0.34) | KMT2AKDM4ETDP1 | |
| SCHEMBL2328383 | 0.79 | KDM4E (0.41) | KLKB1KMT2AKDM4ETDP1 | |
| SCHEMBL2330103 | 0.77 | KLKB1 (0.35) | KLKB1KDM4ETDP1 | |
| SCHEMBL2820538 | 0.72 | HIF1A (0.31) | TDP1 | |
| SCHEMBL2329158 | 0.71 | KLKB1 (0.34) | KLKB1FPR2 | |
| SCHEMBL30209668 | 0.70 | KMT2A (0.36) | KMT2AGRM2KCNH2 | |
| SCHEMBL3717210 | 0.70 | PTGER1 (0.33) | KMT2AFPR2 | |
| SCHEMBL30281161 | 0.70 | KMT2A (0.38) | KMT2AGRM2KCNH2 | |
| SCHEMBL2327771 | 0.69 | KLKB1 (0.34) | KLKB1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440555-B1 | FLUORINATED AMINOTRIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-05-18 | — | — | EP | claimed |
| US-8580831-B2 | Fluorinated aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-11-12 | — | — | US | claimed |
| WO-2010143116-A1 | FLUORINATED AMINOTRIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-16 | — | — | WO | claimed |
| EP-2440555-B1 | FLUORINATED AMINOTRIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-05-18 | — | — | EP | disclosed |
| US-8580831-B2 | Fluorinated aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-11-12 | — | — | US | disclosed |
| WO-2010143116-A1 | FLUORINATED AMINOTRIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-16 | — | — | WO | disclosed |