Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717169 | 0.92 | MTOR (0.60) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3718606 | 0.92 | MTOR (0.60) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3728020 | 0.86 | MTOR (0.66) | MTORPIK3CAPIK3CD | |
| SCHEMBL14843207 | 0.84 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL14843203 | 0.84 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3723782 | 0.83 | MTOR (0.81) | MTORPIK3CAPIK3CD | |
| SCHEMBL3721950 | 0.83 | MTOR (0.57) | MTORPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL2099033 | 0.82 | MTOR (0.74) | MTORPIK3CA | |
| SCHEMBL3723774 | 0.82 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3R1SMG1 | |
| SCHEMBL3723078 | 0.81 | MTOR (0.56) | MTORPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |