Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.78 |
| ▸ | MTOR | P42345 | 6/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723370 | 0.91 | PIK3CA (0.75) | PIK3CAMTOR | |
| SCHEMBL32396 | 0.88 | PIK3CA (1.00) | PIK3CAMTORPIK3R1 | |
| SCHEMBL32395 | 0.88 | PIK3CA (1.00) | PIK3CAMTORPIK3R1 | |
| SCHEMBL628159 | 0.87 | PIK3CA (0.62) | PIK3CAMTOR | |
| SCHEMBL3720492 | 0.87 | PIK3CA (0.76) | PIK3CAMTOR | |
| SCHEMBL32377 | 0.86 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL32378 | 0.86 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL628855 | 0.86 | PIK3CA (0.76) | PIK3CAMTORPIK3R1 | |
| SCHEMBL3730136 | 0.85 | PIK3CA (0.70) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL3727351 | 0.84 | PIK3CA (0.76) | PIK3CAMTORPIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |