Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726892 | 0.88 | HRH3 (0.48) | HRH3P2RX7PDE10AHTR1A | |
| SCHEMBL1728851 | 0.86 | HRH3 (0.58) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL3730691 | 0.84 | HRH3 (0.53) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL3723428 | 0.84 | HRH3 (0.44) | HRH3P2RX7MCHR1PDE10AHTR1A | |
| SCHEMBL9994794 | 0.79 | HRH3 (0.49) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL346050 | 0.78 | HRH3 (0.56) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL9993125 | 0.78 | HRH3 (0.61) | HRH3HTR3AHRH4PDE10AACACB | |
| SCHEMBL9993658 | 0.74 | HRH3 (0.38) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL9993011 | 0.73 | HRH3 (0.39) | HRH3HTR3AHRH4P2RX7MCHR1 | |
| SCHEMBL9994915 | 0.73 | HRH3 (0.41) | HRH3HTR3AHRH4P2RX7MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393809-B1 | DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-04-30 | — | — | EP | disclosed |
| EP-2393809-A2 | DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089510-A2 | DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-12 | — | — | WO | disclosed |