Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.62 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27601515 | 0.93 | NR1H2 (0.67) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL7277087 | 0.92 | ESR2 (0.57) | NR1H2ESR2ABHD6ESR1MAPT | |
| SCHEMBL3722059 | 0.90 | ESR2 (0.53) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL7277721 | 0.89 | NR1H2 (0.70) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL1265523 | 0.88 | NR1H2 (0.67) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL30390692 | 0.87 | NR1H2 (0.70) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL6438594 | 0.87 | NR1H2 (0.70) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL18209393 | 0.84 | NR1H2 (0.63) | NR1H2ESR2MAPTHRH3 | |
| SCHEMBL1650187 | 0.84 | NR1H2 (0.63) | NR1H2ESR2ABHD6MAPK1ESR1 | |
| SCHEMBL7518743 | 0.84 | NR1H2 (0.66) | NR1H2ESR2ABHD6MAPK1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2393812-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089127-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |