Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | STAT6 | P42226 | 12/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913615 | 0.93 | STAT6 (0.55) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL3721789 | 0.90 | JAK3 (0.56) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL3712394 | 0.88 | JAK3 (0.56) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL912889 | 0.85 | SYK (0.50) | MAPK8MAPK9 | |
| SCHEMBL912890 | 0.85 | SYK (0.50) | MAPK8MAPK9 | |
| SCHEMBL3723340 | 0.82 | MAPK8 (0.42) | JAK3JAK2JAK1MAPK8MAPK9 | |
| SCHEMBL3720754 | 0.81 | JAK3 (0.59) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL913540 | 0.81 | STAT6 (0.57) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL913796 | 0.81 | JAK3 (0.57) | JAK3JAK2JAK1STAT6MAPK8 | |
| SCHEMBL3721804 | 0.81 | JAK3 (0.60) | JAK3JAK2JAK1STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |