Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.84 |
| ▸ | MTOR | P42345 | 7/20 | 0.63 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | ATR | Q13535 | 1/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.55 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629424 | 0.93 | PIK3CA (0.73) | PIK3CAMTORPIK3R1PIK3CG | |
| SCHEMBL32575 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL32574 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL3727351 | 0.91 | PIK3CA (0.76) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL3722450 | 0.89 | PIK3CA (0.83) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL2369788 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3R1PIK3CDCHEK1 | |
| SCHEMBL2369779 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3R1PIK3CDCHEK1 | |
| SCHEMBL442108 | 0.85 | PIK3CA (0.72) | PIK3CAMTOR | |
| SCHEMBL1409574 | 0.84 | PIK3CA (0.85) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL32285 | 0.84 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |