Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718615 | 0.93 | MTOR (0.61) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3721937 | 0.93 | MTOR (0.59) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3722519 | 0.87 | MTOR (0.62) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3721559 | 0.86 | MTOR (0.66) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3722650 | 0.86 | MTOR (0.61) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3723078 | 0.86 | MTOR (0.56) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL628043 | 0.85 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CDCYP2C8 | |
| SCHEMBL3721995 | 0.83 | MTOR (0.70) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3728020 | 0.83 | MTOR (0.66) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3720999 | 0.81 | MTOR (0.57) | MTORPIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |