Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720222 | 0.87 | MAPT (0.46) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL3727412 | 0.85 | MEN1 (0.44) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL3724389 | 0.84 | MEN1 (0.44) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL3723842 | 0.84 | CNR1 (0.46) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL676539 | 0.82 | PARP1 (0.39) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL3724387 | 0.81 | TP53 (0.45) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL3725125 | 0.81 | CNR1 (0.45) | MEN1KMT2APOLBCTDSP1CNR1 | |
| SCHEMBL676481 | 0.78 | HRH2 (0.49) | EGFRGSK3B | |
| SCHEMBL3724370 | 0.78 | MEN1 (0.43) | MEN1KMT2APOLBCTDSP1MAPT | |
| SCHEMBL3724365 | 0.78 | MEN1 (0.42) | MEN1KMT2APOLBCTDSP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |