Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176751 | 0.87 | LCK (0.52) | LCKPI4KBCA1CA2 | |
| SCHEMBL2177852 | 0.83 | LCK (0.48) | LCKPI4KBCA1CA2 | |
| SCHEMBL13326568 | 0.81 | LCK (0.56) | LCKPI4KBCA1CA2 | |
| SCHEMBL30292658 | 0.80 | LCK (0.46) | LCKPI4KBCA1CA2 | |
| SCHEMBL2173294 | 0.79 | LCK (0.54) | LCKPI4KBCA1CA2 | |
| SCHEMBL150084 | 0.79 | LCK (0.58) | LCKPI4KBCA1CA2 | |
| SCHEMBL1796679 | 0.79 | LCK (0.54) | LCKPI4KBCA1CA2 | |
| SCHEMBL24735699 | 0.78 | LCK (0.63) | LCK | |
| SCHEMBL538349 | 0.78 | LCK (0.63) | LCKPI4KBCA1CA2 | |
| SCHEMBL5402789 | 0.77 | LCK (0.52) | LCKPI4KBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |
| WO-2010120388-A1 | OLIGOMER-PROTEIN TYROSINE KINASE INHIBITOR CONJUGATES | NEKTAR THERAPEUTICS (US) | 2010-10-21 | — | — | WO | disclosed |