Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 5/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715572 | 0.95 | PRKDC (0.70) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL3716445 | 0.94 | PRKDC (0.65) | PRKDCPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL13050051 | 0.93 | PRKDC (0.54) | PRKDCPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3725329 | 0.92 | PRKDC (0.64) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL13049345 | 0.91 | PRKDC (0.64) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL3724523 | 0.89 | PRKDC (0.61) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL3721405 | 0.89 | PRKDC (0.61) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL3718685 | 0.88 | PRKDC (0.71) | PRKDCPIK3CAPIK3CBMTORPIK3CD | |
| SCHEMBL13049301 | 0.88 | PRKDC (0.68) | PRKDCPIK3CAPIK3CBPIK3CD | |
| SCHEMBL3718030 | 0.88 | PRKDC (0.68) | PRKDCPIK3CAPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |