SCHEMBL3724770

SCHEMBL3724770

CN(C)CCN(C)c1nc(C(N)=O)cc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 12/20 0.50
KDM4E B2RXH2 1/20 0.48
SYK P43405 1/20 0.46
MCHR1 Q99705 2/20 0.44
PIM1 P11309 1/20 0.42
PIM3 Q86V86 1/20 0.42
CASP1 P29466 1/20 0.41
SLC9A5 Q14940 1/20 0.41
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3720121 0.86 SCN9A (0.55) SCN9AKDM4ECASP1ADORA3
SCHEMBL1734231 0.82 KDM4E (0.71) SCN9AKDM4ECASP1ADORA3
SCHEMBL3724772 0.80 PIM1 (0.44) SCN9ASYKMCHR1PIM1PIM3
SCHEMBL3729041 0.77 SCN9A (0.42) SCN9AKDM4E
SCHEMBL3727410 0.76 SCN9A (0.53) SCN9ACASP1ADORA3
SCHEMBL3725418 0.76 SCN9A (0.57) SCN9ACASP1ADORA3
SCHEMBL3724010 0.75 KDM4E (0.54) SCN9AKDM4ECASP1
SCHEMBL3724727 0.75 SCN9A (0.53) SCN9AKDM4ECASP1ADORA3
SCHEMBL3717917 0.75 SCN9A (0.53) SCN9ACASP1ADORA3
SCHEMBL3721018 0.75 KDM4E (0.54) SCN9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed