Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508219 | 0.91 | MEN1 (0.57) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL1185879 | 0.84 | MEN1 (0.63) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL11094129 | 0.83 | MEN1 (0.58) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL6644290 | 0.82 | MEN1 (0.41) | MEN1KMT2AATMGAACNR1 | |
| SCHEMBL507642 | 0.82 | MEN1 (0.60) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL21669394 | 0.81 | MEN1 (0.53) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL7148607 | 0.81 | MEN1 (0.59) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL14231423 | 0.80 | MEN1 (0.54) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL11196860 | 0.80 | MEN1 (0.58) | MEN1KMT2AATMTACR1OPRM1 | |
| SCHEMBL11198749 | 0.80 | MEN1 (0.58) | MEN1KMT2AATMTACR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107235913-B | Method for efficiently manufacturing high-quality flibanserin on industrial scale | 苏州科伦药物研究有限公司 | 2020-07-10 | — | — | CN | claimed |
| WO-2020026162-A1 | PROCESS FOR THE MULTISTEP CONTINUOUS-FLOW PREPARATION OF FLIBANSERIN | RICHTER GEDEON NYRT. (HU) | 2020-02-06 | — | — | WO | disclosed |
| WO-2010128516-A3 | PROCESS FOR THE PREPARATION OF FLIBANSERIN INVOLVING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2012-11-29 | — | — | WO | disclosed |
| WO-2010128516-A2 | PROCESS FOR THE PREPARATION OF FLIBANSERIN INVOLVING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2010-11-11 | — | — | WO | disclosed |
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |