Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5392136 | 0.88 | PDE5A (0.70) | PDE5AKMT2AKDM4ERXFP1 | |
| SCHEMBL2404751 | 0.75 | PDE5A (0.75) | PDE5AKMT2A | |
| SCHEMBL6447569 | 0.75 | PDE5A (0.78) | PDE5AKMT2AKDM4ERXFP1 | |
| SCHEMBL3581095 | 0.75 | PDE5A (0.68) | PDE5AKMT2AKDM4ERXFP1 | |
| SCHEMBL6442012 | 0.75 | PDE5A (0.70) | PDE5AKMT2AKDM4ERXFP1 | |
| SCHEMBL3579707 | 0.75 | PDE5A (0.74) | PDE5AKMT2A | |
| SCHEMBL3586124 | 0.75 | PDE5A (0.74) | PDE5AKMT2A | |
| SCHEMBL3575681 | 0.74 | PDE5A (0.73) | PDE5AKMT2A | |
| SCHEMBL3586836 | 0.73 | PDE5A (0.72) | PDE5AKMT2A | |
| SCHEMBL3584069 | 0.72 | PDE5A (0.73) | PDE5AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035891-A1 | Pharmaceutically Active Compounds | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035891-A1 | Pharmaceutically Active Compounds | PDE5A, PDE3A, PDE3B | PDE5A 1/4885KMT2A 4553/4885HIF1A 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.