Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.39 |
| ▸ | CDK2 | P24941 | 8/20 | 0.39 |
| ▸ | FLT3 | P36888 | 8/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726038 | 1.00 | TYK2 (0.42) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3719074 | 0.90 | TYK2 (0.43) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3719063 | 0.90 | TYK2 (0.43) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL13013511 | 0.89 | IRAK4 (0.35) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3722113 | 0.87 | TYK2 (0.42) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3722105 | 0.87 | TYK2 (0.42) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3775476 | 0.87 | TYK2 (0.55) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3769496 | 0.87 | TYK2 (0.55) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3769510 | 0.87 | TYK2 (0.55) | TYK2CCNE1CDK2FLT3 | |
| SCHEMBL3728768 | 0.86 | TYK2 (0.45) | TYK2CCNE1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | claimed |
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8389527-B2 | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2240488-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |