Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.71 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728551 | 1.00 | HRH3 (0.83) | HRH3KCNH2PTAFR | |
| SCHEMBL3722153 | 0.96 | HRH3 (0.80) | HRH3KCNH2PTAFR | |
| SCHEMBL3726390 | 0.95 | HRH3 (0.79) | HRH3KCNH2PTAFR | |
| SCHEMBL3804701 | 0.91 | HRH3 (1.00) | HRH3KCNH2PTAFR | |
| SCHEMBL3731178 | 0.91 | HRH3 (0.82) | HRH3KCNH2PTAFR | |
| SCHEMBL3732887 | 0.89 | HRH3 (1.00) | HRH3KCNH2PTAFR | |
| SCHEMBL7760919 | 0.88 | HRH3 (0.81) | HRH3KCNH2PTAFR | |
| SCHEMBL4945034 | 0.88 | HRH3 (0.81) | HRH3KCNH2PTAFR | |
| SCHEMBL3672339 | 0.88 | HRH3 (1.00) | HRH3KCNH2PTAFR | |
| Hydrochloric Acid SCHEMBL3814118 | 0.87 | HRH3 (0.80) | HRH3KCNH2PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | claimed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | claimed |
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-11-27 | — | — | US | claimed |
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | HRH3 2/4885KCNH2 581/4885PTAFR 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.