Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 8/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723500 | 0.87 | MEN1 (0.60) | MTORMEN1KMT2AATRCHEK1 | |
| SCHEMBL3723498 | 0.87 | MEN1 (0.60) | MTORMEN1KMT2AATRCHEK1 | |
| SCHEMBL3721205 | 0.82 | MEN1 (0.54) | MTORMEN1KMT2AATRCHEK1 | |
| SCHEMBL3721210 | 0.82 | MEN1 (0.54) | MTORMEN1KMT2AATRCHEK1 | |
| SCHEMBL628567 | 0.81 | KMT2A (0.46) | MTORMEN1KMT2AMAPK14PIK3CA | |
| SCHEMBL2710100 | 0.76 | MTOR (0.55) | MTORPIK3C3PIK3CAPIK3CD | |
| SCHEMBL2710104 | 0.76 | MTOR (0.55) | MTORPIK3C3PIK3CAPIK3CD | |
| SCHEMBL1408910 | 0.75 | MTOR (0.59) | MTORMEN1KMT2APIK3CA | |
| SCHEMBL1408907 | 0.75 | MTOR (0.59) | MTORMEN1KMT2APIK3CA | |
| SCHEMBL2708898 | 0.74 | MTOR (0.54) | MTORPIK3C3PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |