Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 13/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628470 | 0.85 | MTOR (0.58) | NPSR1MAPTMTORPIK3CAUSP2 | |
| SCHEMBL8218959 | 0.84 | PIK3CA (0.59) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL3598858 | 0.83 | PIK3CA (0.61) | MTORPIK3CAPIK3CGHTTPIK3CD | |
| SCHEMBL3935094 | 0.83 | PIK3CA (0.49) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL3722063 | 0.83 | PIK3CA (0.61) | NPSR1MAPTTSHRMAPK1HSD17B10 | |
| SCHEMBL3932966 | 0.82 | ATR (0.56) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL2370172 | 0.82 | PIK3CA (0.71) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL3596872 | 0.82 | PIK3CA (0.62) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL4193910 | 0.81 | GAA (0.48) | MTORPIK3CAPIK3CGGAAPIK3CD | |
| SCHEMBL627786 | 0.81 | MTOR (0.62) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |