Serine

Serine

SCHEMBL3727121

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nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.46
GLRA1 P23415 1/20 0.43
SLC6A9 P48067 1/20 0.43
OR51E2 Q9H255 1/20 0.43
SLC1A1 P43005 5/20 0.43
SLC1A3 P43003 5/20 0.42
SLC1A2 P43004 5/20 0.42
GRIK1 P39086 3/20 0.41
GRIA2 P42262 3/20 0.41
GRIA4 P48058 3/20 0.41
GRIK3 Q13003 3/20 0.41
GRIK5 Q16478 3/20 0.41
GSR P00390 2/20 0.41
GRIA1 P42261 2/20 0.41
GRIK2 Q13002 2/20 0.41
GRM8 O00222 1/20 0.41
GRM6 O15303 1/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Serine SCHEMBL8015848 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL17072284 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
(D)-Serine SCHEMBL4961438 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL28448731 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL1579756 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL1579758 1.00 SLC7A5 (0.46) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL9448210 0.91 SLC7A5 (0.54) SLC7A5SLC1A1SLC1A3SLC1A2GRIK1
(D)-Serine SCHEMBL2029988 0.91 SLC7A5 (0.54) SLC7A5SLC1A1SLC1A3SLC1A2GRIK1
Serine SCHEMBL12500456 0.91 GLRA1 (0.53) SLC7A5GLRA1SLC6A9OR51E2SLC1A1
Serine SCHEMBL8679969 0.91 SLC7A5 (0.54) SLC7A5SLC1A1SLC1A3SLC1A2GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023249029-A1 CONDUCTIVE FILM, SENSOR DEVICE AND METHOD FOR PRODUCING CONDUCTIVE FILM キヤノン株式会社 2023-12-28 WO disclosed
EP-2797641-B1 FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGENERATION AND INFLAMMATION RESPONSES TUFTS COLLEGE (US) 2019-07-10 EP disclosed
US-20180361015-A1 Silk-Based Adhesives NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-12-20 US disclosed
WO-2017095782-A1 SILK-BASED ADHESIVES TUFTS UNIVERSITY (US) 2017-06-08 WO disclosed
US-20150010630-A1 FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGENERATION AND INFLAMMATION RESPONSES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-01-08 US disclosed
EP-2797641-A1 FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGENERATION AND INFLAMMATION RESPONSES Trustees Of Tufts College (US) 2014-11-05 EP disclosed
WO-2013102193-A1 FUNCTIONALIZATION OF BIOMATERIALS TO CONTROL REGENERATION AND INFLAMMATION RESPONSES TRUSTEES OF TUFTS COLLEGE (US) 2013-07-04 WO disclosed
US-7825083-B2 Synovial fluid barrier SPINE WAVE, INC. (US) 2010-11-02 US disclosed
WO-2006086404-A2 SYNOVIAL FLUID BARRIER SPINE WAVE, INC. (US) 2006-08-17 WO disclosed
US-20060178743-A1 Synovial fluid barrier SPINE WAVE, INC. 2006-08-10 US disclosed