Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.91 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940209 | 1.00 | HRH3 (0.91) | HRH3KCNH2PTAFR | |
| SCHEMBL4946499 | 0.99 | HRH3 (0.93) | HRH3KCNH2PTAFR | |
| SCHEMBL3727192 | 0.95 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3668013 | 0.95 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL4943231 | 0.90 | HRH3 (0.90) | HRH3KCNH2PTAFR | |
| SCHEMBL3666533 | 0.90 | HRH3 (0.90) | HRH3KCNH2PTAFR | |
| SCHEMBL3724889 | 0.89 | HRH3 (0.87) | HRH3KCNH2 | |
| SCHEMBL3722330 | 0.86 | HRH3 (0.90) | HRH3KCNH2PTAFR | |
| SCHEMBL3731130 | 0.84 | HRH3 (0.80) | HRH3KCNH2PTAFR | |
| SCHEMBL4944936 | 0.84 | HRH3 (0.66) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | claimed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | claimed |