Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55791 | 0.80 | MTOR (0.70) | MTORPIK3CA | |
| SCHEMBL1408711 | 0.79 | MTOR (0.58) | MTORPIK3CA | |
| SCHEMBL55812 | 0.79 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL56563 | 0.78 | PIK3CA (0.59) | MTORPIK3CA | |
| SCHEMBL55555 | 0.77 | MTOR (0.68) | MTORPIK3CA | |
| SCHEMBL3721321 | 0.77 | HSD17B10 (0.48) | MTORTSHRMAPK1HSD17B10ACP1 | |
| SCHEMBL628064 | 0.76 | MAPT (0.55) | MTORTSHRMAPK1HSD17B10PIK3CA | |
| SCHEMBL7878949 | 0.75 | PIK3CA (0.57) | MTORPIK3CA | |
| SCHEMBL628146 | 0.75 | MTOR (0.57) | MTORPIK3CAMAPTMEN1KMT2A | |
| SCHEMBL3724096 | 0.75 | MTOR (0.57) | MTORPIK3CAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120987-A1 | RING FUSED, UREIDOARYL- AND CARBAMOYLARYL-BRIDGED MORPHOLINO-PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |