Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 3/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027139 | 0.87 | LRRK2 (0.32) | LRRK2TTK | |
| SCHEMBL3268644 | 0.86 | LRRK2 (0.33) | MAPTLRRK2TTK | |
| SCHEMBL1277673 | 0.85 | TTK (0.36) | MAPTLRRK2TTK | |
| SCHEMBL1277678 | 0.85 | TTK (0.36) | MAPTLRRK2TTK | |
| SCHEMBL15005710 | 0.83 | LRRK2 (0.32) | MAPTLRRK2TTK | |
| SCHEMBL15005401 | 0.82 | LRRK2 (0.31) | LRRK2 | |
| SCHEMBL1277591 | 0.81 | TTK (0.33) | LRRK2TTK | |
| SCHEMBL1277587 | 0.81 | TTK (0.33) | LRRK2TTK | |
| SCHEMBL3024171 | 0.81 | — | — | |
| SCHEMBL3024165 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178869-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025477-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |