Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.72 |
| ▸ | RAF1 | P04049 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718908 | 0.90 | MTOR (0.72) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3729266 | 0.90 | MTOR (0.72) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3723351 | 0.89 | MTOR (0.73) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3721513 | 0.89 | PIK3CA (0.65) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3722385 | 0.87 | PIK3CA (0.75) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3728423 | 0.86 | MTOR (0.74) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL3722292 | 0.85 | MTOR (0.74) | MTORPIK3CARAF1PDGFRBKIT | |
| SCHEMBL55907 | 0.83 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL13828916 | 0.81 | MTOR (0.76) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3989822 | 0.80 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |