Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1974801 | 0.90 | CYP2C9 (0.52) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1971399 | 0.86 | KCNH2 (0.69) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1970513 | 0.86 | CYP2C9 (0.54) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1973687 | 0.84 | CYP2C9 (0.77) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1971873 | 0.82 | CYP2C9 (0.51) | CYP2C9CYP2C19KCNH2MAP2K1LCK | |
| SCHEMBL1972540 | 0.81 | CYP2C9 (0.49) | CYP2C9CYP2C19KCNH2MAP2K1LCK | |
| SCHEMBL1971020 | 0.80 | CYP2C9 (0.62) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1971011 | 0.76 | CYP2C9 (0.43) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL1615188 | 0.75 | KCNH2 (0.52) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 | |
| SCHEMBL3465702 | 0.74 | KCNH2 (0.69) | CYP2C9CYP2C19KCNH2MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293763-B2 | 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents | GENENTECH, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293763-B2 | 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents | GENENTECH, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293763-B2 | 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents | GENENTECH, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2231662-B1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH INC (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. | 2010-11-04 | — | — | US | disclosed |
| WO-2009085980-A1 | 8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | GENENTECH, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280063-A1 | 8-ANILINOIMIDAZOPYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS | MAP3K8, MAPK8, MAP3K1 | CYP2C9 1838/4885CYP2C19 2035/4885KCNH2 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.