Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 5/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10151578 | 0.90 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL725152 | 0.90 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL725196 | 0.89 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL724663 | 0.86 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL14822803 | 0.85 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL18966051 | 0.78 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL726023 | 0.77 | PIK3CB (0.48) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL725869 | 0.76 | PIK3CB (0.51) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL18937092 | 0.72 | PIK3CB (0.43) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL10124842 | 0.71 | PIK3CB (0.48) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432321-B1 | THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-06-14 | — | — | EP | disclosed |
| US-8410095-B2 | Thiazolopyrimidinone derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-04-02 | — | — | US | disclosed |
| WO-2010135504-A1 | THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-11-25 | — | — | WO | disclosed |