Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743009 | 0.90 | EPHX2 (0.40) | HDAC3CYP2C9HDAC1HDAC6METAP2 | |
| SCHEMBL3734662 | 0.90 | EPHX2 (0.40) | HDAC3CYP2C9HDAC1HDAC6METAP2 | |
| SCHEMBL3734664 | 0.90 | EPHX2 (0.40) | HDAC3CYP2C9HDAC1HDAC6METAP2 | |
| SCHEMBL13040918 | 0.90 | EPHX2 (0.40) | HDAC3CYP2C9HDAC1HDAC6METAP2 | |
| SCHEMBL3743011 | 0.90 | EPHX2 (0.40) | HDAC3CYP2C9HDAC1HDAC6METAP2 | |
| SCHEMBL13040694 | 0.85 | CASR (0.41) | HDAC3CYP2C9HDAC1HDAC6LMNA | |
| SCHEMBL13040691 | 0.85 | CASR (0.41) | HDAC3CYP2C9HDAC1HDAC6LMNA | |
| SCHEMBL13040740 | 0.85 | CASR (0.41) | HDAC3CYP2C9HDAC1HDAC6LMNA | |
| SCHEMBL13040689 | 0.85 | SLC6A2 (0.49) | LMNACASR | |
| SCHEMBL13040688 | 0.85 | SLC6A2 (0.49) | LMNACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100279936-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2010-11-04 | — | — | US | claimed |
| US-20100279936-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279936-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | C1R, C3AR1, PTH1R | HDAC3 354/4885CYP2C9 361/4885HDAC1 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.