Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Racecadotril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME known ✓ | P08473 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | NR1H2 | P55055 | 1/20 | 1.00 |
| ▸ | PPARA | Q07869 | 1/20 | 1.00 |
| ▸ | NR1H3 | Q13133 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.73 |
| ▸ | ECE1 | P42892 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexecadotril SCHEMBL1649041 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Ecadotril SCHEMBL48974 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Racecadotril SCHEMBL16098141 | 0.99 | CYP1A2 (0.98) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Dexecadotril SCHEMBL28209442 | 0.94 | CYP1A2 (0.88) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10955802 | 0.94 | PPARA (0.88) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Racecadotril SCHEMBL16098344 | 0.91 | CYP1A2 (0.82) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8165601 | 0.89 | CYP1A2 (0.80) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10956150 | 0.89 | CYP1A2 (0.80) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10952774 | 0.87 | CYP1A2 (0.78) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10956142 | 0.87 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2288 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4680203-A1 | COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS | Prolevi Bio AB (SE) | 2026-01-21 | — | — | EP | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| WO-2025075711-A1 | METHODS AND MATERIALS FOR TREATING HYPEROXALEMIA AND/OR HYPEROXALURIA | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2025-04-10 | — | — | WO | claimed |
| CN-119236095-A | Inflammatory microenvironment responsive cross-linked polypeptide modified liposome | 大理大学 | 2025-01-03 | — | — | CN | claimed |
| WO-2024189127-A1 | COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS | PROLEVI BIO AB (SE) | 2024-09-19 | — | — | WO | claimed |
| CN-118557518-A | Racecadotril nano suspension and preparation method thereof | 天津汉瑞药业有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-117503707-B | Taste-masking microsphere and preparation process and application thereof | 哈尔滨市康隆药业有限责任公司 | 2024-08-23 | — | — | CN | claimed |
| US-12064443-B2 | Compositions and methods for treating diseases associated with drug washout due to fluid secretion | VANESSA RESEARCH HOLDINGS, INC. (US) | 2024-08-20 | — | — | US | claimed |
| CN-118490667-A | Orosity membrane, racecadotril orosity membrane agent, preparation method and preparation equipment thereof | 上海欣峰制药有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118453567-A | Application of racecadotril or metabolite derivative thereof in preparing medicament for preventing and treating nervous system diseases | 河北医科大学 | 2024-08-09 | — | — | CN | claimed |
| WO-2000061549-A2 | PHARMACEUTICAL COMPOUNDS | NICOX S.A. (FR) | 2000-10-19 | — | — | WO | claimed |
| WO-2000061541-A2 | PHARMACEUTICAL COMPOUNDS | NICOX S.A. (FR) | 2000-10-19 | — | — | WO | claimed |
| WO-2000061537-A2 | PHARMACEUTICAL COMPOUNDS | NICOX S.A. (FR) | 2000-10-19 | — | — | WO | claimed |
| EP-0820439-B1 | METHOD FOR THE ASYMMETRICAL SYNTHESIS OF S-ACYLATED DERIVATIVES OF 2-MERCAPTOMETHYL 3-PHENYL PROPANOIC ACID, AND USE THEREOF FOR SYNTHESISING N-(MERCAPTOACYL) AMINO ACID DERIVATIVES | BIOPROJET SOC CIV (FR) | 2000-05-03 | — | — | EP | claimed |
| US-6013829-A | REDUCING A MALONIC DIESTER, HYDRIDING TO OBTAIN A DIOL, ACETYLATING TO OBTAIN A MONOESTER, OXIDATION, SAPONIFICATION AND THIOACYLATING; ENZYME INHIBITORS; PROTEASES; OPTICS; ANTISECRETORY AND HYPOTENSIVE AGENTS | SOCIETE CIVILE BIOPROJET (FR) | 2000-01-11 | — | — | US | claimed |
| EP-0937710-A1 | Method for producing an optically active phenylpropionic acid derivative | Ajinomoto Co., Inc. (JP) | 1999-08-25 | — | — | EP | claimed |
| EP-0729936-B1 | Process for the synthesis of alpha substituted acrylic acids and N-(mercaptoacyl)amino acids | BIOPROJET SOC CIV (FR) | 1999-07-07 | — | — | EP | claimed |
| US-5403824-A | Administering a opioid, opioid-degrading enzyme inhibitor or enkephalin secretagogues or mixtures thereof; side effect reduction | THE PROCTER & GAMBLE COMPANY (US) | 1995-04-04 | — | — | US | claimed |
| US-5084007-A | Method for chemical promotion of the effects of low current transcranial electrostimulation | MALIN DAVID H (US) | 1992-01-28 | — | — | US | claimed |
| WO-1991001756-A1 | METHOD FOR CHEMICAL PROMOTION OF THE EFFECTS OF LOW CURRENT TRANSCRANIAL ELECTROSTIMULATION | SKOLNICK MALCOLM H (US) | 1991-02-21 | — | — | WO | claimed |