Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 18/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727463 | 0.91 | DHODH (0.81) | DHODHFFAR4 | |
| SCHEMBL3726595 | 0.90 | DHODH (0.83) | DHODHFFAR4 | |
| SCHEMBL13974154 | 0.87 | DHODH (0.80) | DHODH | |
| SCHEMBL3732070 | 0.81 | DHODH (0.61) | DHODHKDM4E | |
| SCHEMBL3728325 | 0.81 | DHODH (0.67) | DHODHKDM4E | |
| SCHEMBL3726597 | 0.81 | DHODH (0.61) | DHODHFFAR4 | |
| SCHEMBL727817 | 0.80 | DHODH (1.00) | DHODHFFAR4 | |
| SCHEMBL290518 | 0.79 | DHODH (0.81) | DHODH | |
| SCHEMBL3873083 | 0.78 | DHODH (0.68) | DHODH | |
| SCHEMBL3875117 | 0.77 | DHODH (0.68) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691852-B2 | Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors | AMIRALL, S.A. (ES) | 2014-04-08 | — | — | US | disclosed |
| US-20120294854-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | LABORATORIOS ALMIRALL, S.A. | 2012-11-22 | — | — | US | disclosed |
| US-8258308-B2 | Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2012-09-04 | — | — | US | disclosed |
| EP-2121614-B1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL SA (ES) | 2012-06-20 | — | — | EP | disclosed |
| US-20100074898-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| EP-2121614-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | Almirall, S.A. (ES) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077639-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074898-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, NQO2, DAO | DHODH 1/4885KDM4E 2755/4885FFAR4 3400/4885 |
| US-20120294854-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, NQO2, DAO | DHODH 1/4885KDM4E 2755/4885FFAR4 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.