Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.86 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | ATM | Q13315 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
| ▸ | RELA | Q04206 | 2/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.70 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | KRAS | P01116 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169633 | 1.00 | ABCG2 (0.86) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL3733260 | 0.91 | ABCG2 (0.86) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL2458579 | 0.88 | ABCG2 (1.00) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL2458577 | 0.88 | ABCG2 (1.00) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL5471625 | 0.87 | ABCG2 (1.00) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL8461357 | 0.87 | ABCG2 (0.88) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL31436359 | 0.87 | ABCG2 (1.00) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL8977129 | 0.87 | ABCG2 (0.88) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL8461354 | 0.87 | ABCG2 (0.88) | ABCG2TNFRSF1AMEN1KMT2AATM | |
| SCHEMBL5471618 | 0.87 | ABCG2 (1.00) | ABCG2TNFRSF1AMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | ABCG2 3975/4885TNFRSF1A 3647/4885MEN1 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.