SCHEMBL373368

SCHEMBL373368

[CH2]Nc1ccccc1[N+](=O)[O-]

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
L3MBTL1 Q9Y468 3/20 0.60
ALDH1A1 P00352 3/20 0.60
CASP7 P55210 1/20 0.60
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
HSD17B10 Q99714 1/20 0.54
MAPT P10636 7/20 0.53
GAA P10253 3/20 0.53
PKM P14618 1/20 0.53
KAT2B Q92831 2/20 0.51
RAB9A P51151 3/20 0.50
NPC1 O15118 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
KCNMA1 Q12791 1/20 0.49
POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL397773 0.82 MAPK1 (0.77) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL12205174 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL728448 0.78 MEN1 (0.61) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL30198949 0.78 TDP1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL856759 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL950729 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL973213 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL297021 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL4793372 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7
SCHEMBL355102 0.78 MAPK1 (0.60) MAPK1TDP1L3MBTL1ALDH1A1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023209855-A1 ADDITION TYPE POLYMER AND SILICONE HYDROGEL LENS MATERIAL 株式会社メニコン 2023-11-02 WO disclosed
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
EP-3992695-A1 OPHTHALMIC MEDICAL INSTRUMENT INCLUDING PHOTOCHROMIC POLYMER AND PRODUCTION METHOD FOR OPHTHALMIC MEDICAL INSTRUMENT Menicon Co., Ltd. (JP) 2022-05-04 EP disclosed
CN-114096911-A Ophthalmic medical devices comprising photochromic polymers and methods of making the same 株式会社目立康 2022-02-25 CN disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-112703213-A Polymer material 株式会社目立康 2021-04-23 CN disclosed
WO-2021020512-A1 DRUG-CONTAINING OPHTHALMIC LENS 興和株式会社 2021-02-04 WO disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed
EP-0381005-A2 Ocular lens material Menicon Co., Ltd. (JP) 1990-08-08 EP disclosed