Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.65 |
| ▸ | JAK1 | P23458 | 12/20 | 0.65 |
| ▸ | TYK2 | P29597 | 10/20 | 0.65 |
| ▸ | JAK3 | P52333 | 10/20 | 0.65 |
| ▸ | NEK2 | P51955 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890126 | 0.91 | JAK2 (0.53) | JAK2JAK1TYK2JAK3ALOX5AP | |
| SCHEMBL2801987 | 0.86 | JAK2 (0.78) | JAK2JAK1TYK2JAK3CA12 | |
| SCHEMBL2801182 | 0.81 | JAK2 (0.80) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2798916 | 0.79 | JAK2 (0.77) | JAK2JAK1TYK2JAK3NEK2 | |
| SCHEMBL2795550 | 0.78 | JAK2 (0.75) | JAK2JAK1TYK2JAK3NEK2 | |
| SCHEMBL2798952 | 0.78 | JAK2 (0.72) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2798738 | 0.78 | JAK2 (1.00) | JAK2JAK1TYK2JAK3ALOX5AP | |
| SCHEMBL2800131 | 0.78 | JAK2 (0.75) | JAK2JAK1TYK2JAK3NEK2 | |
| SCHEMBL22511743 | 0.78 | JAK2 (0.68) | JAK2JAK1TYK2JAK3NEK2 | |
| SCHEMBL2800134 | 0.77 | JAK2 (0.73) | JAK2JAK1TYK2JAK3NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155201-A2 | QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES | Novartis Ag (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148867-A2 | QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES | NOVARTIS AG (CH) | 2008-12-11 | — | — | WO | disclosed |