Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.48 |
| ▸ | RXRA | P19793 | 7/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.48 |
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14937861 | 0.93 | NR1H2 (0.49) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL21172949 | 0.93 | NR1H2 (0.49) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL30686503 | 0.93 | NR1H2 (0.49) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL25705133 | 0.93 | NR1H2 (0.49) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL15649218 | 0.88 | NR1H2 (0.47) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL1195959 | 0.86 | NR1H2 (0.51) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL1195957 | 0.86 | NR1H2 (0.51) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL3728233 | 0.85 | HDAC2 (0.40) | NR1H2RXRANR1H3HTR1AHTR2A | |
| SCHEMBL6748743 | 0.81 | NR1H2 (0.43) | NR1H2RXRANR1H3MAPK1BACE1 | |
| SCHEMBL17586462 | 0.79 | KDM1A (0.43) | USP30OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-8299058-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-8299058-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-8299058-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100280049-A1 | ANTAGONISTS OF PGD2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280049-A1 | ANTAGONISTS OF PGD2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2009061676-A2 | ANTAGONISTS OF PGD2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| EP-1697376-B1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| EP-1697376-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | Syngenta Participations AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061512-A1 | SPIRO-CONDENSED INDOLINE DERIVATES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280049-A1 | ANTAGONISTS OF PGD2 RECEPTORS | PTGDR2, PTGDR, LTB4R2 | NR1H2 52/4885RXRA 702/4885NR1H3 105/4885 |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, RO60 | NR1H2 1294/4885RXRA 734/4885NR1H3 1891/4885 |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, CHRM3 | NR1H2 1548/4885RXRA 1117/4885NR1H3 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.