Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.55 |
| ▸ | NEK2 | P51955 | 5/20 | 0.54 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740658 | 0.94 | PLK1 (0.57) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3734876 | 0.90 | NEK2 (0.68) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3735865 | 0.88 | PLK1 (0.52) | PLK1PLK3NEK2SLKPDGFRB | |
| SCHEMBL3749178 | 0.87 | PLK1 (0.64) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3734761 | 0.84 | PLK1 (0.67) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3729223 | 0.84 | PLK1 (0.62) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3737509 | 0.83 | PLK1 (0.60) | PLK1PLK3NEK2SLKMAP4K4 | |
| SCHEMBL3731989 | 0.82 | PLK1 (0.68) | PLK1PLK3NEK2SLKKDR | |
| SCHEMBL3736555 | 0.82 | PLK1 (0.66) | PLK1PLK3NEK2SLKKDR | |
| SCHEMBL3739968 | 0.82 | PLK1 (0.68) | PLK1PLK3NEK2SLKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273890-B2 | Thiophene-imidazopyridines | 4SC AG (DE) | 2012-09-25 | — | — | US | disclosed |
| US-20100278833-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2010-11-04 | — | — | US | disclosed |
| WO-2009003911-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278833-A1 | THIOPHENE-IMIDAZOPYRIDINES | PIKFYVE, PIP4K2B, PIP5K1B | PLK1 642/4885PLK3 1528/4885NEK2 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.