Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.32 |
| ▸ | FDPS | P14324 | 9/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31214559 | 1.00 | TSHR (0.33) | TSHRTHRBGGPS1FDPSDNM1 | |
| Bromide SCHEMBL31505736 | 1.00 | TSHR (0.33) | TSHRTHRBGGPS1FDPSDNM1 | |
| Bromide SCHEMBL30892231 | 1.00 | TSHR (0.33) | TSHRTHRBGGPS1FDPSDNM1 | |
| Bromide SCHEMBL31505735 | 1.00 | TSHR (0.33) | TSHRTHRBGGPS1FDPSDNM1 | |
| Bromide SCHEMBL30286082 | 1.00 | TSHR (0.33) | TSHRTHRBGGPS1FDPSDNM1 | |
| SCHEMBL4651000 | 0.97 | TSHR (0.35) | TSHRTHRBGGPS1FDPSSMPD1 | |
| SCHEMBL30892230 | 0.97 | TSHR (0.35) | TSHRTHRBGGPS1FDPSSMPD1 | |
| SCHEMBL5408751 | 0.97 | TSHR (0.35) | TSHRTHRBGGPS1FDPSSMPD1 | |
| SCHEMBL6648399 | 0.97 | TSHR (0.35) | TSHRTHRBGGPS1FDPSSMPD1 | |
| SCHEMBL30404441 | 0.97 | TSHR (0.35) | TSHRTHRBGGPS1FDPSSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829609-B2 | Composition, article and their production method, and film and its production method | FUJIFILM CORPORATION (JP) | 2010-11-09 | — | — | US | disclosed |
| EP-2025711-A1 | Composition, article and their production method, and film and its production method | Fujifilm Corporation (JP) | 2009-02-18 | — | — | EP | disclosed |
| US-20090029169-A1 | excellent transparency; low thermal expansion; hybrid; surface-modified cellulose crystal in resin matrix; surfactant and inorganic ion adsorbed; modified with an organic group; bonded to silicon oxide, titanium oxide, aluminum oxide, zirconium oxide, barium oxide or hydroxyapatite; molding material | FUJIFILM CORPORATION (JP) | 2009-01-29 | — | — | US | disclosed |
| US-3992432-A | Phase transfer catalysis of heterogeneous reactions by quaternary salts | CONTINENTAL OIL COMPANY (US) | 1976-11-16 | — | — | US | disclosed |