Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.70 |
| ▸ | MAOB | P27338 | 3/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.62 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | P4HB | P07237 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740803 | 0.92 | MAOB (0.74) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL31233188 | 0.84 | MAPT (1.00) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL30383393 | 0.84 | MAPT (1.00) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL25203580 | 0.84 | MAPT (1.00) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL25206778 | 0.84 | MAPT (1.00) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL31574484 | 0.83 | CXCL12 (1.00) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL3746445 | 0.81 | CYP1A1 (0.58) | MAPTCXCL12MAOBCYP2D6ALDH1A1 | |
| SCHEMBL31574565 | 0.81 | MAPT (0.85) | MAPTRAB9ANPC1NPSR1CXCL12 | |
| SCHEMBL11816722 | 0.80 | CYP1A1 (0.87) | MAPTCXCL12MAOBMAOACYP1A1 | |
| SCHEMBL11816718 | 0.80 | CYP1A1 (0.87) | MAPTCXCL12MAOBMAOACYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | MAPT 2958/4885RAB9A 1267/4885NPC1 2212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.