Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13078653 | 0.88 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL13045247 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3734547 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3753897 | 0.86 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3740530 | 0.86 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3741094 | 0.85 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3752274 | 0.85 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3742038 | 0.85 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3746193 | 0.85 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL3734296 | 0.85 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834039-B2 | Oxadiazole compounds | ABBOTT LABORATORIES (US) | 2010-11-16 | — | — | US | claimed |