Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28906594 | 0.89 | TSHR (0.58) | TSHRTDP1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL93695 | 0.87 | — | — | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL27850354 | 0.85 | TSHR (0.52) | TSHRLMNAALDH1A1L3MBTL1MAPT | |
| SCHEMBL3733099 | 0.84 | TSHR (0.44) | TSHRTDP1LMNAALDH1A1L3MBTL1 | |
| 1,4-Butanediol SCHEMBL3731846 | 0.84 | TSHR (0.70) | TSHRLMNAALDH1A1MAPTMEN1 | |
| Ethylene Glycol SCHEMBL3741947 | 0.84 | TSHR (0.70) | TSHRLMNAALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL27744210 | 0.84 | — | — | |
| Propylene Glycol SCHEMBL28403048 | 0.84 | TSHR (0.67) | TSHRLMNAALDH1A1L3MBTL1MAPT | |
| Propylene Glycol SCHEMBL7855448 | 0.82 | MAPT (0.61) | TSHRLMNAMAPTMEN1KMT2A | |
| Hexadecanoic Acid Methyl Ester SCHEMBL28256139 | 0.82 | MAPT (0.61) | TSHRLMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |
| CN-101044221-A | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEM IND (JP) | 2007-09-26 | — | — | CN | disclosed |