⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31696702 | 1.00 | — | — | |
| SCHEMBL31696692 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1188891 | 0.97 | — | — | |
| SCHEMBL17107730 | 0.90 | — | — | |
| SCHEMBL733463 | 0.76 | — | — | |
| SCHEMBL733462 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL736326 | 0.74 | — | — | |
| SCHEMBL2898699 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL736327 | 0.74 | — | — | |
| SCHEMBL18492722 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072480-B | Chiral (-) -5-azaspiro [2.4] heptane-7-alcohol, preparation method and application | 常州佳德医药科技有限公司 | 2022-09-30 | — | — | CN | claimed |
| EP-1973407-B1 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2011-11-23 | — | — | EP | claimed |
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | CHEN GUOQING PAUL | 2011-09-29 | — | — | US | claimed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | claimed |
| CN-115466755-B | Method for preparing (-) -5-azaspiro [2,4] heptane-7-ol by asymmetric reduction of carbonyl reductase | 常州佳德医药科技有限公司 | 2025-07-29 | — | — | CN | disclosed |
| CN-115466755-B | Method for preparing (-) -5-azaspiro [2,4] heptane-7-ol by asymmetric reduction of carbonyl reductase | 常州佳德医药科技有限公司 | 2025-07-29 | — | — | CN | disclosed |
| US-20250179059-A1 | ANTICANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2025-06-05 | — | — | US | disclosed |
| CN-119894871-A | Pyrimidine compounds as kinase inhibitors having biological activity against EGFR mutants | 南京爱德程医药科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| EP-4536652-A1 | BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS | Advenchen Pharmaceuticals, LLC (US) | 2025-04-16 | — | — | EP | disclosed |
| EP-4536652-A1 | BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS | Advenchen Pharmaceuticals, LLC (US) | 2025-04-16 | — | — | EP | disclosed |
| EP-4536652-A1 | BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS | Advenchen Pharmaceuticals, LLC (US) | 2025-04-16 | — | — | EP | disclosed |
| US-12162870-B2 | Anticancer compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-12-10 | — | — | US | disclosed |
| EP-2340244-A1 | COMPOUNDS AND METHODS OF USE | Xi, Ning (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010111063-A1 | AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE | XI NING (US) | 2010-09-30 | — | — | WO | disclosed |
| US-20100239576-A1 | AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| WO-2010045095-A1 | COMPOUNDS AND METHODS OF USE | XI NING (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20100093727-A1 | COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2010-04-15 | — | — | US | disclosed |
| EP-1973407-A2 | SPIRO COMPOUNDS AND METHODS OF USE | Chen, Guoqing Paul (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007084875-A2 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | disclosed |