SCHEMBL374576

SCHEMBL374576

c1nnnc2onnc12

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL163423 0.67
SCHEMBL374609 0.65
SCHEMBL374761 0.65
SCHEMBL30480058 0.59
SCHEMBL16878838 0.58
SCHEMBL15988627 0.58
SCHEMBL3612033 0.56
SCHEMBL30736054 0.54
SCHEMBL374755 0.54
SCHEMBL374646 0.52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240246959-A1 BENZIMIDAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. (CN) 2024-07-25 US claimed
EP-4242202-A1 BENZIMIDAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Shenzhen Salubris Pharmaceuticals Co., Ltd. (CN) 2023-09-13 EP claimed
US-8314109-B2 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof SANOFI (FR) 2012-11-20 US claimed
US-20100317675-A1 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-12-16 US claimed
EP-2225240-A2 DERIVATIVES OF 6-HETEROCYCLIC-IMIDAZOÝL,2-A¨PYRROINE-2-CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF Sanofi-Aventis (FR) 2010-09-08 EP claimed
WO-2009106750-A2 DERIVATIVES OF 6-HETEROCYCLIC-IMIDAZO[L,2-A]PYRROINE-2-CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF SANOFI-AVENTIS (FR) 2009-09-03 WO claimed
EP-0007643-B1 OXADIAZOLOTRIAZINE DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-02-15 EP claimed
US-20240246959-A1 BENZIMIDAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. (CN) 2024-07-25 US disclosed
EP-4242202-A1 BENZIMIDAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Shenzhen Salubris Pharmaceuticals Co., Ltd. (CN) 2023-09-13 EP disclosed
EP-2238141-B1 SUBSTITUTED ARYLAMIDE DIAZEPINOPYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CAUSED BY ABNORMAL ACTIVITY OF GSK3-BETA SANOFI SA (FR) 2015-01-14 EP disclosed
EP-2160387-B1 HETEROARYLAMIDE PYRIMIDONE COMPOUNDS SANOFI SA (FR) 2014-05-14 EP disclosed
US-8691990-B2 6-heterocyclic imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof SANOFI (FR) 2014-04-08 US disclosed
EP-2321316-B1 SUBSTITUTED PYRIMIDIN-4-ONE DERIVATIVES MITSUBISHI TANABE PHARMA CORP (JP) 2014-03-12 EP disclosed
US-4336380-A FOR USE AS HYPOTENSIVE AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-06-22 US disclosed
US-4336380-A FOR USE AS HYPOTENSIVE AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-06-22 US disclosed
US-4336380-A FOR USE AS HYPOTENSIVE AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-06-22 US disclosed
US-4276417-A TREATMENT OF VASCULAR-CONDITION HYPERTENSION HOFFMANN-LA ROCHE INC. (US) 1981-06-30 US disclosed
US-4276417-A TREATMENT OF VASCULAR-CONDITION HYPERTENSION HOFFMANN-LA ROCHE INC. (US) 1981-06-30 US disclosed
US-4276417-A TREATMENT OF VASCULAR-CONDITION HYPERTENSION HOFFMANN-LA ROCHE INC. (US) 1981-06-30 US disclosed
EP-0007643-A1 Oxadiazolotriazine derivatives F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-02-06 EP disclosed