Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663553 | 0.94 | HDAC2 (0.55) | HDAC1HDAC2CACNA1BCACNA1HHDAC3 | |
| SCHEMBL3662019 | 0.94 | HDAC2 (0.50) | HDAC1HDAC2KDM1ACACNA1BKMT2A | |
| SCHEMBL3746294 | 0.94 | HDAC2 (0.51) | HDAC1HDAC2KDM1ACACNA1BKMT2A | |
| SCHEMBL3746296 | 0.92 | HDAC1 (0.52) | HDAC1HDAC2KDM1ACACNA1BCACNA1H | |
| SCHEMBL3662020 | 0.92 | HDAC1 (0.52) | HDAC1HDAC2KDM1ACACNA1BCACNA1H | |
| SCHEMBL3660290 | 0.90 | HDAC2 (0.55) | HDAC1HDAC2KMT2AHDAC3ALPG | |
| SCHEMBL3660719 | 0.89 | HDAC2 (0.52) | HDAC1HDAC2KDM1AHDAC3ALPG | |
| SCHEMBL3660155 | 0.89 | HDAC2 (0.51) | HDAC1HDAC2KDM1AHDAC3ALPG | |
| SCHEMBL3661187 | 0.88 | HDAC2 (0.56) | HDAC1HDAC2HDAC3ALPGNPC1 | |
| SCHEMBL3661033 | 0.87 | HDAC2 (0.55) | HDAC1HDAC2HDAC3ALPGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292320-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | GILEAD COLORADO, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| EP-2220066-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | Gilead Colorado, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009079391-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | GILEAD COLORADO, INC. (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292320-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC7, HDAC5 | HDAC1 1/4885HDAC2 4/4885KDM1A 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.