⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050212 | 0.70 | — | — | |
| SCHEMBL3124111 | 0.67 | — | — | |
| SCHEMBL6050339 | 0.63 | — | — | |
| SCHEMBL1298750 | 0.62 | — | — | |
| SCHEMBL3122255 | 0.62 | — | — | |
| SCHEMBL194411 | 0.60 | — | — | |
| SCHEMBL477065 | 0.60 | — | — | |
| SCHEMBL477089 | 0.60 | — | — | |
| SCHEMBL4557137 | 0.59 | S1PR1 (0.38) | — | |
| SCHEMBL8655281 | 0.59 | KCNH2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771446-B1 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |
| EP-1771446-A2 | AZAINDOLE INHIBITORS OF MTP AND APOB | Merck Patent GmbH (DE) | 2007-04-11 | — | — | EP | claimed |
| WO-2006010423-A2 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2006-02-02 | — | — | WO | claimed |
| US-7838533-B2 | Azaindole inhibitors of MTP and ApoB | MERCK PATENT GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| EP-1771446-B1 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1771446-A2 | AZAINDOLE INHIBITORS OF MTP AND APOB | Merck Patent GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010423-A2 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |