Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748969 | 0.85 | TOP1 (0.51) | TOP1LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL8810834 | 0.83 | CYP1A2 (0.53) | TOP1ALDH1A1USP2POLBNTRK1 | |
| SCHEMBL3738458 | 0.80 | TOP1 (0.64) | TOP1NTRK1TSHR | |
| SCHEMBL3736280 | 0.78 | TOP1 (0.48) | TOP1LMNAHSD17B10NTRK1TSHR | |
| SCHEMBL3736256 | 0.77 | RECQL (0.47) | TOP1MAPTKMT2AMAPK1GAA | |
| SCHEMBL16895266 | 0.76 | ABCG2 (0.53) | TOP1KDM4EALDH1A1USP2MAPT | |
| SCHEMBL3741092 | 0.76 | TOP1 (0.56) | TOP1LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL3741087 | 0.76 | TOP1 (0.56) | TOP1LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL16895272 | 0.72 | NPC1 (0.51) | LMNAKDM4EPOLBMAPTHTT | |
| SCHEMBL16904338 | 0.72 | FABP3 (0.49) | LMNAKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829567-B2 | Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-09 | — | — | US | disclosed |